Workshop | Water Activity - Dublin, Ireland

Residual moisture content is a critical quality parameter for freeze-dried and Oral Solid Dosage pharmaceutical products and exists in different forms. Only the relatively “free”, in contrast to the more “bound”, water is capable of inducing degradation events within the product. However, for historical reasons, the global pharmaceutical industry standardised on total water content as the primary moisture quality parameter. The traditional moisture analysis techniques used by the industry, gravimetric or Karl Fischer (KF) titration methods, cannot distinguish between the different water states. Most other industries (for example, the food industry) have standardised on a measurement of water activity as the primary moisture quality parameter.

Scientific investigation has concluded that water activity is a far better predictor of product safety and stability than Karl Fischer water content.

This workshop is designed to provide delegates with the knowledge and tools required to develop a customised Water Activity strategy and roadmap that covers the entire product life cycle, from formulation development to final product testing.

In addition to technical presentations from our Water Activity Application Experts, the workshop will feature industry case studies and in-depth laboratory demonstrations that will give delegates practical insights and hands-on experience.

• What is water activity and how does it differ from other moisture measurements?

• When and why should you be measuring the headspace water?

• Headspace Water activity measurement principles.

• Regulatory context

• Lyo cycle optimization

• Water activity vs Karl Fisher, making a direct correlation with dynamic vapor sorption.

• Water activity determination in oral solid dosage and bulk dry materials.

• Industry Case Study (Formulation development, Process optimization, QC)

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